Ni-catalyzed arylation of alkynes with organoboronic acids and aldehydes to access stereodefined allylic alcohols
Si-Chen Tao, Fancheng Meng, Tie Wang, Yan‐Long Zheng
Abstract
oxidation state manipulation and arylative coupling in one single catalytic cycle. This reaction features a direct and flexible approach for the preparation of stereodefined arylated allylic alcohols with broad substrate scope under mild conditions. The utility of this protocol is demonstrated through the synthesis of diverse biologically active molecular derivatives.
Topics & Concepts
Allylic rearrangementCatalysisNucleophileChemistryCombinatorial chemistrySubstrate (aquarium)Organic chemistryBiologyEcologyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis