TDP-43 induces EMT and promotes hepatocellular carcinoma metastasis via activating Wnt/β-catenin signaling pathway.
Feixia Guo, Hongwei Wang, Min Jiang, Qingguo Yang, Qi Xiang, Hongyin Zhou, Xuemei Hu, Kaixuan Hao, Jie Yang, Hongwen Cao, Zhifa Shen
Abstract
mRNA and regulate the level of GSK3β protein translation. Taken together, our findings suggest that TDP-43 may activate the Wnt/β-catenin pathway by targeting the inhibition of GSK3β protein translation, thus inducing the proliferation and metastasis of HCC cells, which supports its potential value as a therapeutic target for the treatment of metastatic HCC.
Topics & Concepts
Wnt signaling pathwayGene knockdownCancer researchMetastasisEpithelial–mesenchymal transitionCateninDownregulation and upregulationBeta-cateninHepatocellular carcinomaSignal transductionBiologyChemistryCell cultureCancerMedicineCell biologyInternal medicineGeneGeneticsBiochemistryWnt/β-catenin signaling in development and cancerCancer-related gene regulationEpigenetics and DNA Methylation