Fibroblast Activation Protein (FAP) targeting homodimeric FAP inhibitor radiotheranostics: a step to improve tumor uptake and retention time.
Euy Sung Moon, Sanjana Ballal, Madhav P. Yadav, Chandrasekhar Bal, Yentl Van Rymenant, Sarah Stephan, An Bracke, Pieter Van der Veken, Ingrid De Meester, Frank Roesch
Abstract
and thus, the use of dimeric structures could be the next step towards prolonged uptake of FAP inhibitors resulting in radiotherapeutic analogs of FAP inhibitors.
Topics & Concepts
Fibroblast activation protein, alphaIn vivoDOTAChemistryLipophilicityIC50In vitroCancer researchChelationCancerMedicineBiochemistryInternal medicineBiologyOrganic chemistryBiotechnologyPeptidase Inhibition and AnalysisTissue Engineering and Regenerative MedicineConnective tissue disorders research