Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
Azhar O. El-Abd, Said M. Bayomi, Ashraf K. El‐Damasy, Basem Mansour, Naglaa I. Abdel-Aziz, Magda A. El‐Sherbeny
Abstract
were identified as the most potent tubulin polymerization inhibitors with promising cytotoxic activity and excellent binding mode in the docking study.
Topics & Concepts
CombretastatinTubulinThiazoleHeLaChemistryStereochemistryDocking (animal)MoietyPolymerizationMicrotubuleIn vitroCombinatorial chemistryBiochemistryBiologyOrganic chemistryNursingPolymerCell biologyMedicineSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsClick Chemistry and Applications