Mouse Subcutaneous BCG Vaccination and Mycobacterium tuberculosis Infection Alter the Lung and Gut Microbiota
Fabiola Silva, Raphaël Enaud, Elizabeth Creissen, Marcela Henao‐Tamayo, Laurence Delhaès, Angelo Izzo
Abstract
The microbial communities in gut and lung are important players that may modulate the immunity against tuberculosis or other infections as well as impact the vaccine efficacy. We discovered that vaccination through the subcutaneous route affect the composition of gut and lung bacteria, and this might influence susceptibility and defense mechanisms against tuberculosis. Through these studies, we can identify microbial communities that can be manipulated to improve vaccine response and develop treatment adjuvants.
Topics & Concepts
Mycobacterium tuberculosisVaccinationTuberculosisImmunologyImmunityGut floraLungTuberculosis vaccinesBCG vaccineBiologyImmune systemMicrobiologyMedicinePathologyInternal medicineGut microbiota and healthImmune responses and vaccinationsTuberculosis Research and Epidemiology