Molecular mechanisms linking stress and insulin resistance
Habib Yaribeygi, Mina Maleki, Alexandra E. Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
Abstract
To date, there is ample evidence to support the strong relationship between stress and insulin resistance. While diabetes mellitus acts as a potent stress inducer, stress may be an upstream event for insulin resistance as well. It is widely recognized that diabetes mellitus is more prevalent among people who have a stressful lifestyle; however, the underlying mechanisms are not well understood. In the current study, we surveyed the scientific literature for possible interactions between stress and insulin resistance and found that stress can impair glucose homeostasis, working through at least six molecular pathways.
Topics & Concepts
Insulin resistanceDiabetes mellitusInsulinBioinformaticsResistance (ecology)MedicineStress (linguistics)HomeostasisEndocrinologyInternal medicineBiologyLinguisticsPhilosophyEcologyAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismDiet, Metabolism, and Disease