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Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximilian Billmann, Michael Costanzo, Amy H.Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Ušaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiß, Patricia Mero, James W. Dennis, Anne‐Claude Gingras, Chad L. Myers, Brenda Andrews, Charles Boone, Jason Moffat

2020Nature Metabolism122 citationsDOIOpen Access PDF

Topics & Concepts

BiologyLipid metabolismFatty acid synthaseFatty acid synthesisFatty acidGeneGenetic screenLipid dropletBiochemistryFatty acid metabolismMutantCell biologyRNA Research and SplicingCRISPR and Genetic EngineeringRNA and protein synthesis mechanisms
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism | Litcius