Replacing piperidine in solid phase peptide synthesis: effective Fmoc removal by alternative bases
Giulia Martelli, Paolo Cantelmi, Chiara Palladino, Alexia Mattellone, Dario Corbisiero, Tommaso Fantoni, Alessandra Tolomelli, Marco Macis, Antônio Ricci, Walter Cabri, Lucia Ferrazzano
Abstract
Solid Phase Peptide Synthesis (SPPS) is a key technology for the production of pharmaceutical grade peptides and the replacement of piperidine with alternative bases is a piece of the puzzle moving toward a greener technology.
Topics & Concepts
PiperidineCombinatorial chemistryPeptide synthesisChemistryPeptideSolid-phase synthesisPhase (matter)Organic chemistryNanotechnologyStereochemistryMaterials scienceBiochemistryChemical Synthesis and AnalysisChemistry and Chemical EngineeringInnovative Microfluidic and Catalytic Techniques Innovation