Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries
Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane Rivera, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod, Aaron K. Sato
Abstract
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Topics & Concepts
AntibodyMonoclonal antibodyVirologyPeptide libraryPhage displayEpitopeNeutralizing antibodyComplementarity determining regionBiologyComputational biologyEpitope mappingPeptide sequenceGeneImmunologyGeneticsMonoclonal and Polyclonal Antibodies ResearchSARS-CoV-2 and COVID-19 ResearchBacteriophages and microbial interactions