Amplification of oxidative stress<i>via</i>intracellular ROS production and antioxidant consumption by two natural drug-encapsulated nanoagents for efficient anticancer therapy
Yihuan Liu, Haibin Liu, Li Wang, Yingjie Wang, Chengcheng Zhang, Changping Wang, Yan Yang, Jingpin Fan, Guanghui Xu, Qiang Zhang
Abstract
experiments revealed that the CA and DATS-encapsulated nanoagent suppressed tumors more efficiently as compared with the single drug-loaded ones, and the tumor-targeted delivery further enhanced the therapeutic efficacy. This study suggests that the combined enhancement of oxidative stress by CA and DATS could be a promising strategy for cancer therapy.
Topics & Concepts
Oxidative stressAntioxidantIntracellularChemistryDrugNatural (archaeology)Oxidative phosphorylationAnticancer drugReactive oxygen speciesProduction (economics)Consumption (sociology)Food scienceCell biologyPharmacologyBiochemistryBiologyEconomicsArtAestheticsPaleontologyMacroeconomicsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanocluster Synthesis and Applications