Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
Chen Chen, Qidi Ai, Axi Shi, Nan Wang, Lina Wang, Yuhui Wei
Abstract
Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in various plant foods and Chinese herbal medicines. Accumulating evidence indicates that OA and UA exhibit neuroprotective effects on multiple brain disorders. Therefore, this paper reviews researches of OA and UA on neurodegenerative diseases, neuropsychiatric diseases and other brain disorders including ischemic stroke, epilepsy, etc, as well as the potential underlying molecular mechanisms.
Topics & Concepts
Ursolic acidOleanolic acidNeuroprotectionMedicinePharmacologyDiseaseNeuroinflammationNeuroscienceParkinson's diseaseBioinformaticsHuman brainDopamineTriterpenoidHuman healthDopaminergicNeurodegenerationDementiaTraditional medicineNatural product bioactivities and synthesisGenomics, phytochemicals, and oxidative stressCurcumin's Biomedical Applications