METTL3 regulates m6A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma
Zhiwei Zhang, Xufei Teng, Fu Zhao, Chunhui Ma, Jing Zhang, Ling-Feng Xiao, Yaning Wang, Mengqi Chang, Yongji Tian, Chunde Li, Zhang Zhang, Shuhui Song, Wei‐Min Tong, Pinan Liu, Yamei Niu
Abstract
A methylation in SHH-MB, indicative of a potential role of METTL3 as therapeutic target in SHH-MB.
Topics & Concepts
MedulloblastomaGLI2PTCH1Sonic hedgehogGLI1Hedgehog signaling pathwaySmoothenedHedgehogCancer researchGLI3VismodegibMethylationBiologyCell biologySignal transductionTranscription factorGeneticsGeneRepressorRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research