Bioinspired nanocatalytic tumor therapy by simultaneous reactive oxygen species generation enhancement and glutamine pathway-mediated glutathione depletion
Huijia Mao, Yangyang Wen, Yonghui Yu, Hongyan Li, Jing Wang, Baoguo Sun
Abstract
. This work not only paves a new way for rationally designing multi-functional nanozymes for achieving high therapeutic efficacy, but also provides new insights into the construction of bioinspired synergetic therapy by combining CDT and a key anticancer pathway.
Topics & Concepts
GlutamineReactive oxygen speciesGlutathioneOxygenCancer researchBiophysicsBiochemistryMaterials scienceChemistryMedicineBiologyEnzymeOrganic chemistryAmino acidNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery