The innate immune response of self-assembling silk fibroin hydrogels
Natalia Gorenkova, Manfred F. Maitz, Georg Böhme, Hani A. Alhadrami, Essam H. Jiffri, John D. Totten, Carsten Werner, H Carswell, F. Philipp Seib
Abstract
was corroborated by histology, immunofluorescence and murine whole blood analyses. Overall, this study confirms that silk fibroin hydrogels induce a similar immune response to that of PEG hydrogels, while also demonstrating the power of non-invasive bioluminescence imaging for monitoring tissue responses.
Topics & Concepts
FibroinSelf-healing hydrogelsBiocompatibilityIn vivoInnate immune systemSILKPolyethylene glycolImmune systemMaterials scienceChemistryBiomedical engineeringImmunologyMedicineBiologyBiochemistryMetallurgyPolymer chemistryComposite materialBiotechnologySilk-based biomaterials and applicationsAntimicrobial Peptides and ActivitiesNeurobiology and Insect Physiology Research