Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022
Kimberly Marsh, Rachel Tayler, Louisa Pollock, Kirsty Roy, Fatim Lakha, Antonia Ho, David Henderson, Titus Divala, Sandra Currie, David Yirrell, Michael Lockhart, Maria K. Rossi, Nick Phin
Abstract
On 31 March 2022, Public Health Scotland was alerted to five children aged 3-5 years admitted to hospital with severe hepatitis of unknown aetiology. Retrospective investigation identified eight additional cases aged 10 years and younger since 1 January 2022. Two pairs of cases have epidemiological links. Common viral hepatitis causes were excluded in those with available results. Five children were adenovirus PCR-positive. Other childhood viruses, including SARS-CoV-2, have been isolated. Investigations are ongoing, with new cases still presenting.
Topics & Concepts
MedicineEpidemiologyEtiologyPediatricsPublic healthHepatitisRetrospective cohort studyHepatitis AViral hepatitisHepatitis CViral diseaseHepatitis a virusAutoimmune hepatitisEl NiñoYoung adultMEDLINEHepatitis BPublic hospitalVirus-based gene therapy researchCOVID-19 Clinical Research StudiesParvovirus B19 Infection Studies