Synthesis and biological evaluation of diaryl urea derivatives designed as potential anticarcinoma agents using de novo structure-based lead optimization approach
Fereshteh Azimian, Maryam Hamzeh‐Mivehroud, Javid Shahbazi Mojarrad, Salar Hemmati, Siavoush Dastmalchi
Topics & Concepts
ChemistrySorafenibMAPK/ERK pathwayKinaseIn silicoLead compoundCell cycle checkpointApoptosisCell growthDocking (animal)In vitroIC50Cell cycleCell cultureBiochemistryCancer researchBiologyNursingHepatocellular carcinomaMedicineGeneGeneticsSynthesis and biological activityCancer Mechanisms and TherapyEnzyme function and inhibition