Nuclear NAD <sup>+</sup> homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells
Xiangguo Shi, Yajian Jiang, Ayumi Kitano, Tianyuan Hu, Rebecca Murdaugh, Yuan Li, Kevin A. Hoegenauer, Rui Chen, Koichi Takahashi, Daisuke Nakada
Abstract
Nuclear NAD + homeostasis governed by NMNAT1 prevents apoptosis in AML stem cells by suppressing p53.
Topics & Concepts
NAD+ kinaseStem cellApoptosisMyeloid leukemiaHomeostasisCell biologyLeukemiaCancer researchBiologyChemistryBiochemistryImmunologyEnzymeHistone Deacetylase Inhibitors ResearchAutophagy in Disease and TherapyRNA Interference and Gene Delivery