The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity
Coco Chu, Christopher N. Parkhurst, Wen Zhang, Lei Zhou, Hiroshi Yano, Mohammad Arifuzzaman, David Artis
Abstract
or treatment with alarmins or cytokines including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP). ILC2s also express acetylcholine receptors (AChRs), and ACh administration promotes ILC2 cytokine production and elicits expulsion of helminth infection. In accordance with this, ChAT deficiency in ILC2s leads to defective ILC2 responses and impaired immunity against helminth infection. Together, these results reveal a previously unrecognized role of the ChAT-ACh pathway in promoting type 2 innate immunity to helminth infection.
Topics & Concepts
Innate lymphoid cellAcetylcholineImmunologyHelminthsImmunityBiologyLymphopoiesisCytokineInnate immune systemCell biologyImmune systemHaematopoiesisEndocrinologyStem cellIL-33, ST2, and ILC PathwaysEosinophilic EsophagitisImmune Cell Function and Interaction