Regulation of neonatal IgA production by the maternal microbiota
Qinghui Mu, Brianna Swartwout, Michael Edwards, Jing Zhu, Grace Lee, Kristin Eden, Xavier Cabana-Puig, Dylan K. McDaniel, Jiangdi Mao, Leila Abdelhamid, Rebecca M. Brock, Irving C. Allen, Christopher M. Reilly, Xin Luo
Abstract
, which is enriched in the milk of immunodeficient dams. Moreover, we show that while the production of neonatal IgA is dependent on neonatal T cells, the immunodeficient maternal microbiota-mediated enhancement of neonatal IgA has a T cell-independent component. Indeed, this enhancement may be dependent on type 3 innate lymphoid cells in the neonatal small intestinal lamina propria. Interestingly, maternal microbiota-induced neonatal IgA does not cross-react with common enteric pathogens. Future investigations will determine the functional consequences of having this extra IgA.