MCTR1 inhibits ferroptosis by promoting NRF2 expression to attenuate hepatic ischemia-reperfusion injury
Jianhong Ye, Jun Peng, Kuanzhi Liu, Tao Zhang, Wenqi Huang
Abstract
MCTR1 exerts a protective effect in several inflammatory disease models, but its role in hepatic HIRI remains unknown. We confirm that the MCTR1 ameliorates ferroptosis-induced hepatic ischemia-reperfusion injury by promoting NRF2 expression. Our study illustrates the mechanism that MCTR1 protects from HIRI and identifies a therapeutic target for liver transplantation ischemia-reperfusion injury from the perspective of ferroptosis.
Topics & Concepts
Reperfusion injuryIschemiaMedicinePharmacologyTransplantationMechanism (biology)Cancer researchInternal medicinePhilosophyEpistemologyFerroptosis and cancer prognosisMicroRNA in disease regulationCircular RNAs in diseases