A Base-Promoted Reductive Coupling Platform for the Divergent Defluorofunctionalization of Trifluoromethylarenes
Shawn E. Wright, Jeffrey S. Bandar
Abstract
We report a trifluoromethylarene reductive coupling method that dramatically expands the scope of difluorobenzylic substructures accessible via C–F bond functionalization. Catalytic quantities of a Lewis base, combined with a disilane reagent in formamide solvent, promotes the replacement of a single trifluoromethyl fluorine atom with a silylated hemiaminal functional group. The reaction proceeds through a difluorobenzyl silane intermediate that can also be isolated. Together, these defluorinated products are shown to provide rapid access to over 20 unique difluoroalkylarene scaffolds.
Topics & Concepts
ChemistryBase (topology)Coupling (piping)Combinatorial chemistryMetallurgyMathematicsMaterials scienceMathematical analysisFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsSynthesis and Reactions of Organic Compounds