Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn’s disease by promoting intestinal inflammation
Gao Tan, Chongyang Huang, Jiaye Chen, Bingxia Chen, Fachao Zhi
Abstract
mice exhibit less-severe intestinal inflammation than WT controls do. Furthermore, our results indicate that GSDME-mediated epithelial-cell pyroptosis induces intestinal inflammation through the release of proinflammatory intracellular contents. In summary, we show that GSDME participates in the pathogenesis of CD through GSDME-mediated pyroptosis to release proinflammatory cytokines.
Topics & Concepts
PyroptosisPathogenesisCrohn's diseaseInflammationDiseaseImmunologyMedicineInflammasomePathologyInflammasome and immune disordersGout, Hyperuricemia, Uric AcidAutoimmune and Inflammatory Disorders Research