Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells
JunHwee Jang, Eun‐Jung Lee
Abstract
MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti3C2 MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression.
Topics & Concepts
Lamellar structureMesenchymal stem cellBiomaterialCell biologyMaterials scienceMXenesMicrostructureChemistryBiophysicsNanotechnologyBiologyComposite materialMXene and MAX Phase MaterialsGraphene and Nanomaterials ApplicationsRNA Interference and Gene Delivery