An Environmentally Benign, Catalyst‐Free N−C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides
Vishal Kumar, Sanjeev Dhawan, Pankaj Sanjay Girase, Parvesh Singh, Rajshekhar Karpoormath
Abstract
Abstract Herein, we report an operationally simple, cheap, and catalyst‐free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram‐scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.
Topics & Concepts
ChemistryEnvironmentally friendlyCatalysisPrimary (astronomy)Combinatorial chemistryYield (engineering)Organic chemistryOrganic synthesisBond cleavageTertiary alcoholsBiologyPhysicsMetallurgyAstronomyMaterials scienceEcologyChemical Synthesis and AnalysisAdvanced Synthetic Organic ChemistryAsymmetric Hydrogenation and Catalysis