Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors
Runlai Liu, Mingxin Huang, Shuai Zhang, Long Li, Mi Li, Jun Sun, Lan Wu, Qi Guan, Weige Zhang
Topics & Concepts
ChemistryColchicineTubulinMicrotubuleApoptosisStereochemistryIn vitroMicrotubule polymerizationIn vivoDocking (animal)ArylCell cycleCell cycle checkpointCell growthCell cultureBiochemistryCell biologyOrganic chemistryBiologyGeneticsBiotechnologyNursingMedicineAlkylSynthesis and biological activitySynthesis and Biological EvaluationSynthesis of heterocyclic compounds