Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
Chrysovalantou E. Xirouchaki, Yaoyao Jia, Meagan J. McGrath, Spencer Greatorex, Melanie Tran, Troy L. Merry, Dawn Hong, Matthew J. Eramo, Sophie C. Broome, Jonathan S. T. Woodhead, Randall F. D’Souza, Jenny Sadler Gallagher, Ekaterina Salimova, Cheng Huang, Ralf B. Schittenhelm, Junichi Sadoshima, Matthew J. Watt, Christina A. Mitchell, Tony Tiganis
Abstract
-detoxifying enzyme GPX-1 or by treating mice with an agonist of NFE2L2, the master regulator of antioxidant defense. These findings causally link NOX4-derived ROS in skeletal muscle with adaptive responses that promote muscle function and insulin sensitivity.
Topics & Concepts
NOX4Skeletal muscleInsulin resistanceOxidative stressNADPH oxidaseReactive oxygen speciesInsulinInternal medicineEndocrinologyBiologyChemistryMedicineCell biologyExercise and Physiological ResponsesAdipose Tissue and MetabolismVitamin C and Antioxidants Research