Epigenetic reader SP140 loss of function drives Crohn’s disease due to uncontrolled macrophage topoisomerases

Hajera Amatullah, Isabella Fraschilla, Sreehaas Digumarthi, Julie Y. Huang, Fatemeh Adiliaghdam, Gracia Bonilla, Lai Ping Wong, Marie-Ève Rivard, Claudine Beauchamp, Virginie Mercier, Philippe Goyette, Ruslan I. Sadreyev, Robert M. Anthony, John D. Rioux, Kate L. Jeffrey