Electrospun Chitosan-Based Nanofibrous Coating for the Local and Sustained Release of Vancomycin
Stefano Serpelloni, Michael Ellis Williams, Sergio Caserta, Shashank Sharma, Maham Rahimi, Francesca Taraballi
Abstract
-glycolic acid) coating was applied, resulting in extended release of up to 7 days. Biocompatibility assessment using human umbilical vein endothelial cells demonstrated successful attachment and viability of the nanofiber patches. Our study provides insights into the development of a drug delivery system for vascular grafts aimed at preventing infection during implantation, highlighting the potential of electrospinning as a promising technique in the field of vascular surgery.
Topics & Concepts
ElectrospinningBiocompatibilityVancomycinNanofiberMaterials scienceBiomedical engineeringChitosanPopulationSurgeryMedicinePolymerChemistryComposite materialOrganic chemistryStaphylococcus aureusBiologyMetallurgyBacteriaEnvironmental healthGeneticsInfectious Aortic and Vascular ConditionsElectrospun Nanofibers in Biomedical ApplicationsPolymer Surface Interaction Studies