A tumor microenvironment dual responsive contrast agent for contrary contrast-magnetic resonance imaging and specific chemotherapy of tumors
Yudie Lu, Jie Feng, Zhiyu Liang, Xuanyi Lu, Shuai Guo, Lin Huang, Wei Xiong, Sijin Chen, Huimin Zhou, Xuehua Ma, Yikai Xu, Xiaozhong Qiu, Aiguo Wu, Xiaoyuan Chen, Zheyu Shen
Abstract
ratio (7.2). Our TME dual responsive SA-FeGdNP-DOX@mPEG significantly enhanced the contrast of MR images between tumors and livers, and the ΔSNR difference reached 501%. In addition, our SA-FeGdNP-DOX2@mPEG2 with tumor targetability and controlled DOX release responding to the TME was also used for tumor-specific chemotherapy with reduced side effects.
Topics & Concepts
Magnetic resonance imagingContrast (vision)Tumor microenvironmentDual modeChemotherapyDynamic contrast-enhanced MRIChemistryMedicineNuclear magnetic resonanceCancer researchRadiologyTumor cellsInternal medicinePhysicsAerospace engineeringEngineeringOpticsLanthanide and Transition Metal ComplexesNanoplatforms for cancer theranosticsMRI in cancer diagnosis