DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies
Sophie Rose, Marie Cuvellier, Frédéric Ezan, Jennifer Carteret, Arnaud Bruyère, Vincent Legagneux, Fabrice Nesslany, Georges Baffet, Sophie Langouët
Topics & Concepts
GenotoxicityToxicityHepatocyteLiver injuryMicronucleusCarcinogenChemistryComet assayPharmacologyDrug metabolismDNA damageDimethyl sulfoxideBiologyMicronucleus testIn vitroMetabolismBiochemistryDNAOrganic chemistryLiver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionCarcinogens and Genotoxicity Assessment