An oxygen-economical nano-photosensitizer with a high photodynamic therapeutic outcome <i>via</i> simultaneous reduction of the cellular respiration and oxygen depletion of PDT
Hao Zhang, Xiaosa Yan, Yongkang Zhang, Chenlu Bao, Changhua Li
Abstract
-PCL. By controlling the length of hydrophobic PCL segments, we successfully optimized the micelle size to around 30 nm for enhanced tumor penetration. The orchestration of the two functional components, ATO and IPS, can simultaneously hinder the two major tumor oxygen-consuming pathways, where ATO targets mitochondrial complex III to inhibit cellular respiration, while IPS generates ROS through a low oxygen-consuming type-I photochemical pathway, enabling remarkable PDT efficacies in both hypoxic cells and a 4T1 tumor-bearing BALB/c mouse model. This work sheds new light on the construction of nano-photosensitizers to rejuvenate PDT against hypoxic solid tumors.
Topics & Concepts
Photodynamic therapyPhotosensitizerOxygenReactive oxygen speciesHypoxia (environmental)Tumor hypoxiaBiophysicsChemistryCancer researchPhotochemistryBiochemistryBiologyMedicineSurgeryRadiation therapyOrganic chemistryNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPhotodynamic Therapy Research Studies