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Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study

Weifeng Ma, Peng Chen, Xian‐Sen Huo, Yufeng Ma, Yanhong Li, Peng-Cheng Diao, Fang Yang, Shengquan Zheng, Meng‐Jin Hu, Wen‐Wei You, Pei‐Liang Zhao

2020European Journal of Medicinal Chemistry46 citationsDOI

Topics & Concepts

ChemistryIn vivoIn vitroCyclin B1ApoptosisTubulinCyclin-dependent kinase 1Cell cycleCell growthCell cycle checkpointMicrotubule polymerizationMicrotubuleBiochemistryCell biologyBiologyBiotechnologySynthesis and biological activityClick Chemistry and ApplicationsQuinazolinone synthesis and applications
Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study | Litcius