Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo
Songxuan Zhang, Yuting Zhang, Yuying Fang, Hao Chen, Mengjiao Hao, Qingyun Tan, Hu Chen, Huihao Zhou, Jun Xu, Qiong Gu
Topics & Concepts
In vivoAndrographolideOsteoclastChemistryOsteoporosisRANKLPharmacologyOvariectomized ratDownregulation and upregulationIn vitroCytotoxicityIC50Western blotInternal medicineBiochemistryActivator (genetics)ReceptorMedicineBiologyGeneHormoneBiotechnologyAndrographolide Research and ApplicationsBone Metabolism and DiseasesPharmacological Effects of Medicinal Plants