In Vivo study of Antidiabetic Activity from Ethanol Extract of Clitoria ternatea L. Flower

Abstract

Background: Clitoria ternatea L. or telang flower is a plant whose all parts have benefits for the human body. The benefits of telang flower include antioxidant, antidiabetic, antiobesity, anticancer, anti-inflammatory, antibiotic and hepatoprotective agent. Clitoria ternatea L. flower as an antidiabetic treatment works by increasing insulin secretion, inhibiting the formation of advanced glucose end products, as well as inhibiting the work of enzymes involved in the production of glucose in the blood. In this study using an experimental method, using 25 mice which were divided into 5 groups. The negative control group (aquadest), the positive control group (glibenclamide 5 mg), and the three groups with variations in the dose of 96% ethanol extract of telang flower 200, 400, 600 mg/kg BW. The results: The results showed that the negative control group did not experience a decrease in blood sugar levels; the positive control group by giving glibenclamide 5 mg experienced a decrease in blood sugar levels of up to 48.6 mg/dl. In 200 mg dose extract; 400; 600 mg of tested animals showed a decrease in blood sugar up to 48.2 mg/dl, 31.2 mg/dl, 43 mg/dl respectively. The conclusion: Based on the data obtained, it was then analyzed statistically using the One Way ANOVA test, resulting in a significant value <0.05, then the Kruskal-Wallis Test was carried out. It could be concluded that there was a significant difference in decreasing blood sugar levels. Different dose of Clitoria ternatea L. extract gives a significant effect on reducing blood sugar levels. Keywords: Antidiabetic, Extract, Clitoria ternatea L., Flower

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