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Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling

Minan Lu, Kegong Xie, Xianzhe Lu, Lu Lu, Yu Shi, Yujin Tang

2020Investigational New Drugs32 citationsDOI

Topics & Concepts

OsteosarcomaCancer researchMesenchymal stem cellViability assayCell growthTumor microenvironmentMedicineCellApoptosisBiologyPathologyBiochemistryTumor cellsGeneticsGinseng Biological Effects and ApplicationsCancer-related molecular mechanisms researchNF-κB Signaling Pathways
Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling | Litcius