Controlling the regioselectivity of the bromolactonization reaction in HFIP
Tuong Anh To, Nhu T. A. Phan, Binh Khanh, Thành Vinh Nguyễn
Abstract
Experimental and computational studies revealed the crucial role of HFIP in regioselectivity-switchable bromolactonization reactions, with the formation of endo -products under kinetic control and exo -products under thermodynamic control.
Topics & Concepts
RegioselectivityChemistryCombinatorial chemistryComputational chemistryOrganic chemistryCatalysisVanadium and Halogenation ChemistryChemical Synthesis and ReactionsInorganic Fluorides and Related Compounds