Oxidative [4+2] Annulation of Pyrrole‐2‐carbaldehyde Derivatives with o‐Hydroxyphenyl Propargylamines: Syntheses of 5,6,7‐Trisubstituted Indolizines
Yu‐Qing Wang, L.‐Y. CHEN, Ruilin Yang, Ming Lang, Jin‐Bao Peng
Abstract
A base promoted oxidative [4+2] annulation of pyrrole-2-carbaldehyde derivatives with o-hydroxyphenyl propargylamines for the synthesis of highly substituted indolizines has been developed. Using DBN as base, a broad range of 5,6,7-trisubstituted indolizines have been prepared in good to excellent yields under mild conditions, and many useful functional groups can be tolerated.
Topics & Concepts
AnnulationPyrroleChemistryOxidative phosphorylationBase (topology)Combinatorial chemistryMedicinal chemistryOrganic chemistryMathematicsCatalysisMathematical analysisBiochemistrySynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsSynthesis and Characterization of Pyrroles