Fecal microbiome and bile acid metabolome in adult short bowel syndrome
Harold J. Boutte, Jacqueline Chen, Todd Wylie, Kristine M. Wylie, Yan Xie, Mackenzie Geisman, Anirudh Prabu, Vered Gazit, Phillip I. Tarr, Marc S. Levin, Brad W. Warner, Nicholas O. Davidson, Deborah C. Rubin
2021American Journal of Physiology-Gastrointestinal and Liver Physiology32 citationsDOIOpen Access PDF
Abstract
Loss of intestinal surface area causes short bowel syndrome, intestinal failure, and parenteral nutrition dependence. We analyzed the gut microbiota and bile acid metabolome of a large cohort of short bowel syndrome adult patients with different postsurgical anatomies. We report a novel analysis of the microbiome of patients with ileostomy and jejunostomy. Enrichment of specific microbial and bile acid species may be associated with the ability to wean from parenteral nutrition.
Topics & Concepts
MetabolomeMicrobiomeFecesBile acidGastroenterologyGut microbiomeMedicineInternal medicineBiologyMicrobiologyBioinformaticsMetaboliteClinical Nutrition and GastroenterologyDiet and metabolism studiesGastrointestinal motility and disorders