CAR T Cell Generation by piggyBac Transposition from Linear Doggybone DNA Vectors Requires Transposon DNA-Flanking Regions
David Bishop, Lisa J. Caproni, Kavitha Gowrishankar, Michał Łęgiewicz, Kinga Karbowniczek, J P Tite, David Gottlieb, Kenneth Micklethwaite
Abstract
transposon to enable effective transposition. dbDNA may further reduce the cost and improve the safety of CAR T cell production with transposon systems.
Topics & Concepts
Transposable elementTransposition (logic)DNAGeneticsBiologySleeping Beauty transposon systemMolecular biologyGeneGenomeComputer scienceArtificial intelligenceCAR-T cell therapy researchViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research