Ligand-controlled regioselective and chemodivergent defluorinative functionalization of <i>gem</i>-difluorocyclopropanes with simple ketones
Leiyang Lv, Huijun Qian, Yangyang Ma, Shiqing Huang, Xiaoyu Yan, Zhiping Li
Abstract
)-F bond as the linchpin for subsequent C-O bond formation. These examples represented an unprecedented ligand-controlled regioselective and chemodivergent approach to various mono-fluorinated terminal alkenes and/or furans from the same readily available starting materials.
Topics & Concepts
RegioselectivitySteric effectsChemistryLigand (biochemistry)BifunctionalNucleophileCombinatorial chemistrySurface modificationAlkylationBond cleavageSelectivityStereochemistryOrganic chemistryCatalysisReceptorBiochemistryPhysical chemistryFluorine in Organic ChemistryCyclopropane Reaction MechanismsN-Heterocyclic Carbenes in Organic and Inorganic Chemistry