RETRACTED ARTICLE: Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM)
Liang Liu, Shan Xiao, Yan Wang, Zifeng Zhu, Yiyao Cao, Sen Yang, Rongkang Mai, Yong Zheng
Abstract
. Next, the underlying mechanisms were investigated, and we found that circZNF652 sponged miR-486-5p to upregulate SERPINE1 in GBM cells. Also, we validated that knock-down of circZNF652 regulated the miR-486-5p/SERPINE1 axis to reverse the malignant phenotypes in GBM cells. Interestingly, we noticed that GBM cells derived exosomes were characterized by high-expressed CircZNF652. Collectively, we concluded that targeting the circular RNA circZNF652/miR-486-5p/SERPINE1 axis was a novel and effective strategy to suppress cancer progression in GBM.
Topics & Concepts
GlioblastomaCascadeCancer researchCircular RNAmicroRNAIdentification (biology)CancerMedicineOncologyInternal medicineBiologyGeneticsGeneChemistryChromatographyBotanyCircular RNAs in diseasesMicroRNA in disease regulationHigh Entropy Alloys Studies