Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency
Joshua E. McGee, Jack R. Kirsch, Devin Kenney, Faith Cerbo, Elizabeth Chavez, Ting‐Yu Shih, Florian Douam, Wilson W. Wong, Mark W. Grinstaff
Topics & Concepts
PotencySubstitution (logic)NucleotideInterferonChemistryRNAPharmacologyBiochemistryBiologyVirologyIn vitroGeneComputer scienceProgramming languageinterferon and immune responsesViral Infections and Immunology ResearchRNA Interference and Gene Delivery