Synthesis and evaluation of the anticancer activity of [Pt(diimine)(<i>N</i>,<i>N</i>-dibutyl-<i>N</i>′-acylthiourea)]<sup>+</sup> complexes
Tebogo Peega, Rachael N. Magwaza, Leonie Harmse, Izak A. Kotzé
Abstract
values for the three active platinum complexes were in the low micromolar range for the three cell lines and ranged between 0.68 μM and 2.28 μM. Changes to cell morphology indicate that the active platinum complexes induce cell death by both apoptosis and paraptosis. The complexes were able to induce the nuclear expression of the cyclin-dependent kinase inhibitor, p21, which is an indicator of DNA damage. The collective data indicate that these platinum complexes are valuable lead compounds for further analysis and cancer drug discovery.
Topics & Concepts
DiimineCisplatinChemistryPlatinumLigand (biochemistry)StereochemistryOxaliplatinApoptosisQuinoxalineCancerColorectal cancerBiochemistryReceptorBiologyOrganic chemistryGeneticsChemotherapyCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMagnetism in coordination complexes