GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis
Guobin Zheng, Yun Zhao, Zhenhao Li, Yunqing Hua, Jing Zhang, Yaodong Miao, Yang Guo, Lan Li, Jia Shi, Zhengwei Dong, Shu Yang, Guanwei Fan, Chuanrui Ma
Abstract
mice. GLSP may be a potential drug candidate for the treatment of atherosclerosis and vascular calcification.
Topics & Concepts
CalcificationABCA1MedicineInflammationAortaCholesterolFoam cellInternal medicineChemistryLipoproteinBiochemistryGeneTransporterBone Metabolism and DiseasesDermatological and Skeletal DisordersClusterin in disease pathology