Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue
Lorenzo R. Sewanan, Shi Shen, Stuart G. Campbell
Abstract
We applied innovative methods to comprehensively characterize the length and load-dependent behaviors of engineered human cardiac muscle when treated with the cardiac β-myosin specific inhibitor mavacamten, a drug on the verge of clinical implementation for hypertrophic cardiomyopathy. We find mechanistic support for the role of mavacamten in improving diastolic function of cardiac tissue and note novel effects on work and power.
Topics & Concepts
ContractilityHypertrophic cardiomyopathyDiastoleCardiologyDiastolic functionCardiac muscleInternal medicineCardiac function curveFunction (biology)CardiomyopathyMyosinMyocyteMedicineHeart failureCell biologyBiologyBlood pressureCardiomyopathy and Myosin StudiesCardiovascular Function and Risk FactorsCardiovascular Effects of Exercise