MUC16/CA125 in cancer: new advances
Xin-Yu Zhang, Lian‐Lian Hong, Zhi‐Qiang Ling
Abstract
• Summarized the limitations of MUC16/CA125 in clinical application, and detailed the improvement and progress of MUC16/CA125 in the early diagnosis and clinical treatment of cancer in recent years. • Emphasized that technological advances have expanded the detection range of MUC16/CA125 and contributed to improving the detection rate of cancer. • Reviewed the existing methods of early tumor diagnosis for MUC16/CA125 and related clinical trials. More accurate identification of sites and auxiliary detection of other factors is an important way to improve the efficiency of early cancer diagnosis. • Summarized the existing clinical therapies targeting MUC16/CA125, and introduced in detail the recent improvements in CAR-T therapy targeting MUC16 and other improvements to improve the efficacy of MUC16 drugs, as well as the clinical trials related to these methods. • Provided a new idea for the development of new specific targeted drugs and the improvement of drug efficacy. MUC16/CA125 is a common diagnostic marker for many types of cancer. However, due to the widespread expression of MUC16 in cancer, its specificity and sensitivity as a target are poor, which severely limits its clinical application. In recent years, various studies have shown that the clinical application potential of MUC16/CA125 has been greatly improved. The update of detection technology improves the accuracy and range of detection, and improves the early diagnosis rate of cancer. Targeting MUC16/CA125 is an important strategy for tumor therapy. Targeting residual amino acids, n-glycoylation structures or other targets on the surface of MUC16 cells can greatly improve the accuracy of detection and therapy. The new drug delivery method broke through the original technical shackles, targeted MUC16 positive cells more specifically and improved the drug efficacy. In this paper, the technological advances in detecting and identifying MUC16 targets and the great progress in cancer screening and treatment based on MUC16 as a target are described in detail, revealing the great potential of MUC16 as a target in cancer screening and treatment, and illustrating the potential clinical application value of MUC16.