Proteome Regulation Patterns Determine Escherichia coli Wild-Type and Mutant Phenotypes
Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert
Abstract
tools, the PAM and related simulation approaches will foster the use of a model-driven metabolic research. Applications range from the investigation of mechanisms of microbial evolution to the determination of optimal strain design strategies in metabolic engineering, thus supporting basic scientists and engineers alike.
Topics & Concepts
ProteomeMetabolic engineeringPhenotypeEscherichia coliBiologySynthetic biologyComputational biologySystems biologyMutantHeterologousProtein engineeringProtein expressionFlux (metallurgy)GeneticsEnzymeBiochemistryGeneChemistryOrganic chemistryMicrobial Metabolic Engineering and BioproductionGene Regulatory Network AnalysisBiofuel production and bioconversion