Vascular endothelium–targeted <i>Sirt7</i> gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model
Shimin Sun, Weifeng Qin, Xiaolong Tang, Yuan Meng, Wenjing Hu, Shuju Zhang, Minxian Qian, Zuojun Liu, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Zhongjun Zhou, Baohua Liu
Abstract
;TC mice. These data support endothelial dysfunction as a primary trigger of systemic aging and highlight gene therapy as a potential strategy for the clinical treatment of HGPS and age-related vascular dysfunction.
Topics & Concepts
ProgeriaLife spanMedicineGeneBiologyGeneticsGerontologyNuclear Structure and FunctionRNA Research and SplicingMitochondrial Function and Pathology