Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer
Ming He, Wentao Ning, Zhiye Hu, Jian Huang, Chune Dong, Hai‐Bing Zhou
Topics & Concepts
ChemistryPharmacophoreDemethylaseEstrogen receptorPharmacologyApoptosisMCF-7Cancer researchCancer cellBiochemistryBreast cancerCancerHistoneBiologyInternal medicineMedicineGeneHuman breastHistone Deacetylase Inhibitors ResearchEstrogen and related hormone effectsEpigenetics and DNA Methylation