Allogeneic ABCB5+ Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial
Andreas Kerstan, Kathrin Dieter, Elke Niebergall‐Roth, Ann-Kathrin Dachtler, Korinna Kraft, Markus Stücker, Georg Daeschlein, Michael Jünger, Tobias Görge, Ulrich Meyer-Pannwitt, Cornelia Erfurt‐Berge, Charlotte von Engelhardt, Andreas Klare, Christiane Pfeiffer, Jasmina Esterlechner, Hannes M. Schröder, Martin Gasser, Ana Maria Waaga-Gasser, Matthias Goebeler, Seda Ballikaya, Samar Sadeghi, Gëorge F. Murphy, Dennis P. Orgill, Natasha Y. Frank, Christoph Ganss, Karin Scharffetter‐Kochanek, Markus H. Frank, Mark A. Kluth
Abstract
MSCs as a potential candidate for adjunctive therapy of otherwise incurable CVUs. These results justify the conduct of a larger, randomized, controlled trial to confirm clinical efficacy.
Topics & Concepts
MedicineMesenchymal stem cellVenous leg ulcerWound healingClinical trialChronic woundAdverse effectRefractory (planetary science)Randomized controlled trialGuidelineStem cellStem-cell therapySurgeryPhases of clinical researchInternal medicineOncologyPathologyPhysicsGeneticsAstrobiologyBiologyWound Healing and TreatmentsDiagnosis and Treatment of Venous DiseasesPressure Ulcer Prevention and Management